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  • Volume 7, Issue S1

Virulence factor activity relationships for hepatitis E and Cryptosporidium

Ronald Fayer, Palmer Orlandi, Michael L. Perdue
Published August 2009, 7 (S1) S55-S63; DOI: 10.2166/wh.2009.044
Ronald Fayer
United States Department of Agriculture, Animal and Natural Resources Institute, Environmental Microbial Safety Laboratory, Beltsville MD, 20705, USA Tel.: +1 301 504 8750 Fax: +1 301 504 6608 E-mail: ronald.fayer@ars.usda.gov
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Palmer Orlandi
Division of Field Science, ORA, Food and Drug Administration, Rockville MD, 20857, USA
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Michael L. Perdue
United States Department of Agriculture, Animal and Natural Resources Institute, Environmental Microbial Safety Laboratory, Beltsville MD, 20705, USA Tel.: +1 301 504 8750 Fax: +1 301 504 6608 E-mail: ronald.fayer@ars.usda.gov
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Abstract

The hepatitis E virus and Cryptosporidium are waterborne pathogens, each consisting of distinct taxa, genotypes and isolates that infect humans, nonhuman animal species or both. Some are associated with disease, others are not. Factors contributing to disease are extremely complicated, possibly involving differences in one or more traits associated with an organism's taxon, genotype or isolate and its infectious dose, and age or condition, as well as the host's physiology and immune status. Potential virulence factors have not yet been identified for HEV. Putative virulence factors for Cryptosporidium might be found in recently recognized genes involved in processes such as excystation, adherence to host cells, invasion, intracellular maintenance and host cell destruction.

  • cryptosporidiosis
  • epidemiology
  • hepatitis
  • molecular
  • proteins
  • taxonomy
  • © IWA Publishing 2009
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Journal of Water and Health: 16 (2)
  Volume 7, Issue S1

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Virulence factor activity relationships for hepatitis E and Cryptosporidium
Ronald Fayer, Palmer Orlandi, Michael L. Perdue
Journal of Water and Health Aug 2009, 7 (S1) S55-S63; DOI: 10.2166/wh.2009.044
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Virulence factor activity relationships for hepatitis E and Cryptosporidium
Ronald Fayer, Palmer Orlandi, Michael L. Perdue
Journal of Water and Health Aug 2009, 7 (S1) S55-S63; DOI: 10.2166/wh.2009.044

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Keywords

cryptosporidiosis
epidemiology
hepatitis
molecular
proteins
taxonomy
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